Job Information
Lilly Advisor - DMPK in San Francisco, California
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
At DICE Therapeutics, a wholly owned subsidiary of Eli Lilly & Company, we design and develop innovative therapies in immunology. Our goal is to help patients with debilitating diseases. We aim to create a future where convenient oral medicines with biologic-like efficacy are available. We are developing oral alternatives to medicines currently limited to injectable forms.
Responsibilities:
We are seeking an Advisor, Drug Metabolism and Pharmacokinetics. This role requires expertise in designing, conducting, and interpreting in vitro ADME and preclinical PK and PK/PD studies. These skills are crucial for advancing DICE's small molecule Discovery & Development portfolio. The successful candidate will have strong laboratory, analytical, and project management skills, along with a solid foundation in drug disposition (ADME) science.
Conduct and/or oversee conduct of in vitro permeability, protein binding and other binding studies, metabolic stability, inhibition, phenotyping, transporters, and/or other in vitro ADME studies
Work with external CROs and vendors to establish, design, perform, and interpret results from in vitro ADME and/or PK studies
Contribute to optimizing workflow from compound submission to in vitro ADME and PK screening data readout
Evaluate new technologies, techniques, study designs, and/or equipment to enhance DMPK support of Discovery & Development programs
Understand application of ADME screening data within Research programs and apply such knowledge to enhance assays and/or the design and development of novel assays
Contribute to and influence the DMPK components in the screening funnel and criteria for compound selection and advancement in research programs. Identify, brainstorm, and resolve ADME/PK issues in research programs. Serve as the DMPK project representative in research programs
Help provide DMPK support to various departments such as Chemistry, Biology/Pharmacology, Toxicology, and Clinical pharmacology
Responsible for writing and/or reviewing DMPK reports
Contribute to nonclinical PK/ADME sections in regulatory documents (e.g., IB, IND, etc…)
Do you have experience with DMPK? Apply today to join the DICE Team!
Basic Requirements:
PhD in a relevant scientific field with 0-5+ years of industry experience
MS in a relevant scientific field with 10+ years of industry experience
Additional Skills/Preferences:
Experience in Drug Discovery/Development DMPK
Strong publication record in the area of ADME/PK coupled with a high level of scientific curiosity and analytical thinking skills
Reasonable knowledge of PK and PK/PD studies to support characterization of small molecule therapeutics in Research programs
Familiarity with quantitative bioanalysis of plasma and other biological matrices is required. This skill supports pharmacokinetic, toxicokinetic, and in vitro ADME analyses of novel small molecule therapeutics
Familiarity with Excel, Prism, WinNonlin Phoenix (non-compartmental PK analysis) and other relevant ADME/DMPK software
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